Abstract
We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m2. At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.
Keywords: COVID-19; SARS-CoV-2; antibodies; sex-related differences.
【저자키워드】 COVID-19, antibodies, SARS-CoV-2, sex-related differences., 【초록키워드】 severe acute respiratory syndrome coronavirus 2, neutralizing antibody, Evolution, coronavirus, Neutralizing antibodies, antibody, Sex, severe acute respiratory syndrome Coronavirus, healthcare worker, polymerase chain reaction, body mass index, Humoral response, anti-N antibodies, sera, age, women, nucleoprotein, BMI, respiratory, Quantitative, Anti-spike, Mild disease, association, humoral, independent of, Chain Reaction, body mass, symptom onset, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, participant, positive, anti-S, male participants, Sex-related differences, men, independent, polymerase chain, collected, faster, individuals, declined, anti-N antibody, male participant, timepoint, with mild disease, 【제목키워드】 coronavirus 2, difference,