Abstract
The wide spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with phenotypes impacting transmission and antibody sensitivity necessitates investigation of immune responses to different spike protein versions. Here, we compare neutralization of variants of concern, including B.1.617.2 (delta) and B.1.1.529 (omicron), in sera from individuals exposed to variant infection, vaccination, or both. We demonstrate that neutralizing antibody responses are strongest against variants sharing certain spike mutations with the immunizing exposure, and exposure to multiple spike variants increases breadth of variant cross-neutralization. These findings contribute to understanding relationships between exposures and antibody responses and may inform booster vaccination strategies.
Keywords: B.1.1.529 (omicron); B.1.617.2 (delta); COVID-19; SARS-CoV-2; antibody escape; immune exposure; natural infection; neutralization; vaccination; variant.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, neutralization, variant, B.1.617.2 (Delta), antibody escape, natural infection, B.1.1.529 (omicron), immune exposure, 【초록키워드】 coronavirus, immune response, antibody, neutralization, Antibody Response, variant, Infection, variants of concern, B.1.617.2, Transmission, severe acute respiratory syndrome Coronavirus, omicron, variants, immune, Spike protein, sensitivity, Antibody responses, spike mutation, immune responses, sera, cross-neutralization, phenotype, B.1.1.529, respiratory, natural infection, Neutralizing antibody response, breadth, booster vaccination, exposure to, Phenotypes, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, individual, neutralizing antibody responses, increase, contribute, spike variant, 【제목키워드】 Delta, response, exposure, strain, Including,