Abstract
It was reported that tuberculosis and BCG vaccination are potential tools for reducing the burden of COVID-19, mainly through the non-specific trained immunity. We have investigated whether BCG vaccination is able to induce cross-reacting antibodies against the SARS-CoV-2. We have tested the induced humoral immune responses against the SARS-CoV-2 Spike in the mouse model, after either BCG or rabies DNA-based vaccination alone or in Prime/Boost approach to COVID-19 DNA-based vaccination. We have demonstrated that BCG vaccination alone was able to induce cross-reacting antibodies to SARS-CoV-2 Spike. It can also boost the antibody response induced by a COVID-19 DNA-based vaccination. Hence, both BCG and latent tuberculosis infection can explain the lower burden of COVID-19 in developing countries, not only through the trained immunity but also by inducing cross-reacting antibodies. Furthermore, with the emergence of different COVID-19 variants, or eventually other Betacoronaviruses, the use of BCG vaccination can help against immune escapes of the current vaccines.
【초록키워드】 COVID-19, antibodies, SARS-CoV-2, vaccination, Immunity, Vaccines, spike, antibody, Tuberculosis, Antibody Response, variants, Immune escape, immune responses, BCG, humoral immune response, mouse model, non-specific, boost, SARS-CoV-2 spike, latent tuberculosis, cross-reacting antibodies, BCG vaccination, latent tuberculosis infection, help, rabies, approach, potential tools, tested, reported, investigated, reducing, demonstrated, induce, explain, the antibody response, potential tool, the SARS-CoV-2, 【제목키워드】 COVID-19, BCG, Model, mouse, induction, Against,