Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants could induce immune escape by mutations of the spike protein which are threatening to weaken vaccine efficacy. A booster vaccination is expected to increase the humoral immune response against SARS-CoV-2 variants in the population. We showed that immunization with two doses of wild type receptor-binding domain (RBD) protein, and booster vaccination with wild type or variant RBD protein all significantly increased binding and neutralizing antibody titers against wild type SARS-CoV-2 and its variants in mice. Only the booster immunization by Omicron (BA.1)RBD induced a strong antibody titer against the omicron virus strain and comparable antibody titers against all the other virus strains. These findings might shed the light on coronavirus disease 2019 booster immunogens.
Keywords: SARS-CoV-2; booster vaccination; humoral immune response.
【저자키워드】 SARS-CoV-2, humoral immune response, booster vaccination, 【초록키워드】 coronavirus disease, severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, Efficacy, Vaccine, coronavirus, Mutation, variant, SARS-CoV-2 variant, vaccine efficacy, severe acute respiratory syndrome Coronavirus, omicron, immunization, variants, Spike protein, Protein, Immune escape, SARS-CoV-2 variants, mice, RBD, Antibody titer, humoral immune response, respiratory, wild type, Antibody titers, booster, RBD protein, Neutralizing antibody titer, binding, booster vaccination, dose, acute respiratory syndrome, acute respiratory syndrome coronavirus, neutralizing antibody titers, domain, immunogens, virus strain, virus strains, significantly increased, the spike protein, induce, comparable, expected, 【제목키워드】 immune response, variant, acute respiratory syndrome, subunit, domain, circulating, elicited,