Abstract
Novel coronavirus disease 2019 (COVID-19) is a highly infectious and deadly disease, spreading worldwide. There are limited data about the clinical course of end-stage renal disease (ESRD) patients infected with COVID-19. However, previous cohort studies showed a high mortality rate of ESRD patients infected with COVID-19. We report here two Japanese ESRD patients confirmed with severe COVID-19 pneumonia. Case 1 was a 60-year-old man with ESRD due to diabetic nephropathy who were infected with COVID-19 and exhibited acute respiratory distress syndrome (ARDS) requiring mechanical ventilation and intensive care unit (ICU) admission. He was treated with tocilizumab and intravenous immunoglobulin (IVIG). After 6 days of treatment in ICU, he was extubated. Case 2 was a 68-year-old woman undergoing maintenance hemodialysis for 17 years who also exhibited ARDS due to COVID-19. Her clinical course resembles case 1. Our experience of these two cases indicates that anti-cytokine therapy might be effective for severe COVID-19 pneumonia in ESRD patients.
Keywords: Acute respiratory distress syndrome (ARDS); Coronavirus disease 2019 (COVID-19); Diabetic nephropathy; End-stage renal disease (ESRD); Intravenous immunoglobulin (IVIG); Tocilizumab.
【저자키워드】 Tocilizumab, Coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), diabetic nephropathy, End-stage renal disease (ESRD), Intravenous immunoglobulin (IVIG), 【초록키워드】 COVID-19, Treatment, coronavirus disease, Respiratory distress syndrome, Coronavirus disease 2019, Intravenous immunoglobulin, ARDS, Severe COVID-19 pneumonia, COVID-19 pneumonia, intensive care, acute respiratory distress syndrome, mechanical ventilation, Tocilizumab, intensive care unit, novel coronavirus disease, IVIG, ICU, cohort study, Novel coronavirus, Clinical course, Hemodialysis, Immunoglobulin, Patient, End-stage renal disease, diabetic nephropathy, Japanese, novel, renal disease, disease, Admission, patients, ESRD, acute respiratory distress, distress, Maintenance hemodialysis, respiratory distress, Diabetic, syndrome, anti-cytokine therapy, renal, high mortality rate, anti-cytokine, effective, nephropathy, were infected, exhibited, treated, indicate, infected with COVID-19, with COVID-19, 【제목키워드】 Treatment, Japanese,