Abstract
Real-world data suggest that protection against COVID-19 declines a few months after vaccination, particularly in the elderly and immunocompromised individuals. Our study aimed to analyze the humoral response induced by a third supplemental dose of BNT162b2 vaccine in a mixed group of immunocompromised individuals by determining anti-spike (anti-S) IgG antibody titers at baseline (pre-third vaccine dose) and 4 weeks after the dose. Serum samples were obtained from a total group of 85 immunocompromised individuals (history of cancer: n = 20, lymphoma: n = 4, leukemia: n = 3, transplant recipients: n = 4, autoimmune disease: n = 42, inflammatory disease: n = 6, autoimmune diabetes type 1: n = 6) all of whom had previously received a two-dose schedule of the vaccine. The average number of days between second and third dose was 139.6145 (±41.39071). The overall IgG GMCs 4 weeks postvaccination were increased by more than 35 times (fold change = 35.30, p < 0.001). Fold changes were not significantly correlated with underlying condition, age, sex nor with days between second and third dose. Considering the predominance of omicron variants in the current period and the results of studies showing a decrease in the effectiveness of the third dose after 10 weeks we highly recommend a fourth dose to this vulnerable population group.
Keywords: BNT162b2 mRNA COVID-19 vaccine; Greece; SARS-CoV-2; antibody titers; immunocompromised adults; immunogenicity; third dose.
【저자키워드】 SARS-CoV-2, immunogenicity, third dose., Greece, Antibody titers, BNT162b2 mRNA COVID-19 vaccine, immunocompromised adults, 【초록키워드】 COVID-19, Vaccine, BNT162b2 vaccine, vaccination, immunogenicity, antibody, Sex, diabetes, real-world data, Omicron variants, vaccine dose, BNT162b2, Autoimmune disease, Humoral response, mRNA, lymphoma, Effectiveness, Immunocompromised, Greece, Omicron variant, age, Autoimmune, change, leukemia, Antibody titers, Anti-spike, BNT162b2 mRNA COVID-19 vaccine, BNT162b2 mRNA, immunocompromised adults, dose, Inflammatory, Decline, humoral, IgG antibody titer, vulnerable population, Fold change, serum samples, autoimmune diabetes, immunocompromised individuals, average, Fold changes, IgG antibody titers, fold, anti-S, inflammatory disease, serum sample, postvaccination, decrease, significantly, correlated, the vaccine, autoimmune diabete, baseline, IgG GMC, immunocompromised individual, of BNT162b2, 【제목키워드】 dose, immunocompromised adult, the SARS-CoV-2,