Abstract
By December 2021, about 80% of people over the age of 12 had been vaccinated in Japan, and almost all people were vaccinated with the mRNA vaccine. We investigated here the anti-spike protein antibody titer at the time of breakthrough infection of SARS-CoV-2 omicron. A total of 32 SARS-CoV2 omicron breakthrough infection was included in the study. The median antibody titer at breakthrough infection was 776 AU/mL overall, of which the median antibody titer of BNT162b2 vaccinated was 633 AU/mL and that of mRNA-1273 vaccinated was 9416 AU/mL. This result suggests that low levels of antibody titers 6 months after vaccination do not provide sufficient antibodies to prevent the omicron variant breakthrough infection, which may occur with a higher anti-spike antibody titer after vaccination with mRNA-1273. However, antibody titers in some patients were comparable to those immediately after the second vaccination with either mRNA vaccine.
Keywords: Anti-spike protein antibody; BNT162b2; Breakthrough infection; Omicron variant; mRNA-1273.
【저자키워드】 mRNA-1273, BNT162b2, Omicron variant, Breakthrough infection, Anti-spike protein antibody, 【초록키워드】 SARS-CoV-2, SARS-CoV2, vaccination, antibody, mRNA vaccine, mRNA-1273, omicron, BNT162b2, Protein, mRNA, Patient, Antibody titer, Japan, Omicron variant, age, Breakthrough infection, Antibody titers, Anti-spike, anti-spike antibody, in some, second vaccination, Prevent, investigated, median, occur, comparable, of BNT162b2, the median, 【제목키워드】 SARS-CoV-2, Protein,