Abstract
We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to 6 months after symptom onset, among 14 early patients with coronavirus disease 2019 in the United States. We isolated viable severe acute respiratory syndrome coronavirus 2 from real-time reverse-transcription polymerase chain reaction-positive respiratory specimens collected during days 0-8 after onset, but not after. All 13 patients with 2 or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of neutralizing antibodies. Eight participants provided serum at 6 months after onset; all retained detectable anti-spike immunoglobulin G, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at 6 months.
Keywords: COVID-19; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Neutralizing antibodies, virus, serum, Immunoglobulin G, Immunoglobulin, antibody kinetics, Patient, United States, respiratory, anti-spike antibodies, Anti-spike, respiratory specimens, symptom onset, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, specimen, participant, acute illness, The United States, polymerase chain, respiratory specimen, collected, reported, detectable, provided, retained, 【제목키워드】 response, shedding, the United State, Confirmed,