Abstract
Current studies focus on cellular and humoral immunity induced by novel SARS-CoV-2 vaccines. Non-responders to vaccinations are not uncommonly encountered in clinical medicine (e.g. in the field of hepatitis B). Whereas vaccine-induced humoral immunity against SARS-CoV-2 is compromised by emerging Variants of Concern (VOCs), cellular immunity against SARS-CoV-2 is emerging as resilient against VOCs. Thus commercially available test kits for diagnostic laboratories designed to evaluate cellular immune responses to SARS-CoV-2 are urgently needed. Here we evaluated the novel QuantiFERON SARS-CoV-2 assay (Qiagen) measuring INF-ɣ release induced by two spike-derived peptide pools (Ag1 and Ag2) in a cohort of health care workers vaccinated with the mRNA-1273 vaccine and confirmed humoral response. Our study indicates the usefulness of this novel assay for routine laboratories to evaluate cellular immunity against SARS-CoV-2 in response to mRNA-1273 vaccination.
Keywords: COVID-19; Cellular immunity; SARS-CoV-2; Serology; Vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, serology, cellular immunity, 【초록키워드】 vaccination, Health care, serology, Cellular immune response, mRNA-1273, health care workers, diagnostic, peptide, SARS-CoV-2 vaccines, Laboratory, Humoral immunity, Cohort, Humoral response, cellular immunity, mRNA, immune responses, VOCs, Health care worker, hepatitis B, novel, concern, clinical medicine, cellular, Vaccinations, Cellular and humoral immunity, humoral, focus, mRNA-1273 vaccine, responders, cellular immune responses, Qiagen, QuantiFERON, current, evaluate, evaluated, indicate, INF-ɣ, peptide pool, 【제목키워드】 Health care worker, QuantiFERON,