Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SARS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in nonsevere cases.
Keywords: COVID-19; IgG; SARS-CoV-2; antibody; immunity.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, antibody, immunity., 【초록키워드】 coronavirus disease, severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, coronavirus, adaptive, Immunity, antibody, Innate immunity, SARS-COV-2 infection, Infection, coronavirus 2, Spread, China, Severe acute respiratory syndrome, immune responses, Patient, Mild, Adaptive immune response, respiratory, patients, Analysis, adaptive immune responses, COVID-19 patient, acute respiratory syndrome, acute respiratory syndrome coronavirus, severe symptoms, Virus-specific IgG, SARS-CoV-2 clearance, common clinical symptoms, shown, examined, subset, severe symptom, did not produce, 【제목키워드】 Antibody Response, COVID-19 patient,