Abstract
We describe an outbreak of SARS-CoV-2 (B.1.351) in a nursing home. At the outbreak onset 96% of residents and 76% of HCW had received two doses of BNT162b2. Twenty-eight residents (28/53) and six HCW (6/33) were infected. Infected residents had lower levels of anti-S antibodies compared to those who were not infected (157 vs 552 U/mL). Among 50 residents with available serological status, nineteen (19/25) with serum concentration < 300 U/mL and seven (7/25) with concentration > 300 U/mL acquired SARS-CoV-2 (RR 2.7 [95 %CI 1.4-5.3]). The quantification of circulating antibodies could be useful in detecting people with an impaired immune response who are at high risk of acquiring and spreading SARS-CoV-2.
Keywords: B.1.351; COVID-19; Outbreak; SARS-CoV-2; Vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, B.1.351, outbreak, 【초록키워드】 immune response, B.1.351, nursing home, BNT162b2, serum, serological, quantification, Concentration, dose, high risk, HCW, circulating antibodies, circulating antibody, anti-S antibody, Seven, were infected, of BNT162b2, 【제목키워드】 vaccination, quantification, circulating antibody,