Introduction . Liver diseases influence musculoskeletal functions and may negatively affect the exercise capacity of patients with cirrhosis. Aim . To test the relationship between the six-minute walk test (6MWT), maximal inspiratory pressure (MIP), and exercise capacity (VO 2peak ) measures and the survival rate of patients with cirrhosis. Methods . This prospective cohort study consisted of 86 patients diagnosed with cirrhosis with the following aetiology: hepatitis C virus (HCV), hepatitis B virus (HBV), and/or alcoholic cirrhosis (AC). All patients were followed up for three years and submitted to the 6MWT, pressure measurements with a compound gauge, and an exercise test (VO 2peak ). Results . The survival analysis showed that the individuals who covered a distance shorter than 410 m during the 6MWT had a survival rate of 55% compared with a rate of 97% for the individuals who walked more than 410 m ( p = 0.0001). Individuals with MIPs below −70 cmH 2 O had a survival rate of 62% compared with a rate of 93% for those with MIPs above −70 cmH 2 O ( p = 0.0001). The patients with values below 17 mL/kg had a survival rate of 55% compared with a rate of 94% for those with values above 17 mL/kg ( p = 0.0001). Conclusion . The 6MWT distance, MIP, and oxygen consumption are predictors of mortality in patients with cirrhosis.
Functional Capacity, Respiratory Muscle Strength, and Oxygen Consumption Predict Mortality in Patients with Cirrhosis
[Category] B형 간염,
[Article Type] Research Article
[Source] PMC
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