In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine ethyl glucuronide (uEtG), assessed concordance between uEtG and Alcohol Use Disorders Identification Test-Consumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink >7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDIT-C. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 117 (14.5%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer ART time (≥12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and care settings.
【저자키워드】 HIV/AIDS, Africa, alcohol use disorder, Hepatitis B virus, ethyl glucuronide, alcohol biomarker,