Abstract
The implementation of vaccination among healthcare workers (HCWs) allowed the management of the pandemic in a manner that differed from that in the first waves. It has been demonstrated that the mRNA vaccines elicit good humoral responses but that there are still breakthrough infections. In summer 2021, a fifth wave emerged, despite the good coverage of HCWs in Spain. We aimed to study the SARS-CoV-2 IgG antibody levels as a marker to predict the possibility of Delta variant infections after vaccination after a seroepidemiological campaign. Of the 5000 participants, a total of 4902 (98.04%) showed a positive result in the serological anti-S test and only 98 (1.96%) were negative. Among the 4368 fully vaccinated participants, only in five cases was the serology negative. Of the total number of participants that received antibody results during the study, 162 were PCR positive in the subsequent two months. Among these, 151 were fully vaccinated (two doses). Significant differences between antibody BAU/mL levels were found between PCR positive and non-PCR positive participants ( p < 0.01). The median of BAU/mL was higher in those vaccinated patients with no infection (1260 BAU/mL; 465-2080) versus infected patients (661 BAU/mL; 361-2080). These data support the idea that vaccines play an important role in the control of the pandemic, especially among HCWs at the time of the Delta variant circulation. More studies with other variants of concern must be performed in order to establish a correlation between the levels of IgG and the new infections.
Keywords: Delta variant; SARS-CoV-2; humoral response.
【저자키워드】 SARS-CoV-2, delta variant, Humoral response, 【초록키워드】 IgG, Vaccine, vaccination, pandemic, Healthcare workers, serology, antibody, mRNA vaccine, Infection, Delta, delta variant, healthcare worker, mRNA vaccines, Coverage, infections, IgG antibody, Humoral response, HCWs, SARS-CoV-2 IgG antibody, management, implementation, Patient, Spain, breakthrough infections, circulation, correlation, serological, summer, predict, marker, humoral, HCW, new infections, no infection, Support, Participants, significant differences, infected patients, These data, PCR positive, other variants, positive result, participant, idea, doses, positive, anti-S, FIVE, performed, subsequent, median, demonstrated, elicit, infected patient, Significant, other variant, the SARS-CoV-2, 【제목키워드】 Delta, response, worker,