Abstract
Congenitally- or perinatally-acquired viral infections can be harmful to the fetus but data are limited about prevalence and outcomes of coronavirus disease 2019 (COVID-19) disease during the first trimester of pregnancy. We report epidemiologic data from a study investigating a cohort of women who became pregnant just before or during the COVID-19 pandemic. We recruited 138 consecutive pregnant women attending for first trimester screening (11-13 weeks of gestation) at Sant’Anna Hospital, Turin, Piedmont, Italy, during the plateau and the falling phase of the COVID-19 epidemic curve. Patients were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin M/immunoglobulin G antibody levels and SARS-CoV-2 detection in sera and nasopharyngeal swab samples. COVID-19 cumulative incidence during the first trimester was of 10.1% with high prevalence of asymptomatic patients (42.8%). Similar to the course of the disease in non pregnant adults, 80% to 90% of infections were not severe.The prevalence of reported symptoms was four-fold higher in SARS-CoV-2 positive patients (57%) than in those negative (13%) (P < .001), suggesting that direct self-testing should open doors to confirmatory testing for COVID-19. Our findings support the need for COVID-19 screening in early pregnancy in epidemic areas to plan materno-fetal health surveillance programs.
Keywords: COVID-19; SARS-CoV-2; first trimester; pregnancy; seroprevalence.
【저자키워드】 COVID-19, SARS-CoV-2, Seroprevalence, Pregnancy, first trimester, 【초록키워드】 coronavirus disease, viral infection, Coronavirus disease 2019, coronavirus, antibody, COVID-19 pandemic, Infection, outcome, Italy, severe acute respiratory syndrome Coronavirus, viral infections, pregnant women, Prevalence, Nasopharyngeal swab, SARS-CoV-2 detection, Adults, Cohort, Epidemic, Pregnancy, Health, Viral, Immunoglobulin, Surveillance, sera, fetus, women, incidence, respiratory, disease, asymptomatic patients, asymptomatic patient, first trimester, Nasopharyngeal swab samples, COVID-19 epidemic, pregnant, immunoglobulin M, open, epidemic curve, early pregnancy, Support, gestation, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, Piedmont, swab samples, cumulative, plateau, SARS-CoV-2 positive patients, Turin, reported symptoms, Course, tested, recruited, the disease, reported symptom, SARS-CoV-2 positive patient, 【제목키워드】 cumulative incidence, first trimester,