Abstract
As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is quick to implement, potentially provides benefits, and has a good safety profile. The therapeutic potential of COVID-19 convalescent plasma (CCP) is likely mediated by antibodies through direct viral neutralization and Fc-dependent functions such as a phagocytosis, complement activation, and antibody-dependent cellular cytotoxicity. In the United States, CCP became one of the most common treatments with more than a half million units transfused despite limited efficacy data. More than a dozen randomized trials now demonstrate that CCP does not provide benefit for those hospitalized with moderate to severe disease. However, similar to other passive antibody therapies, CCP is beneficial for early disease when provided to elderly outpatients within 72 hours after symptom onset. Only high-titer CCP should be transfused. CCP should also be considered for immunosuppressed patients with COVID-19. CCP collected in proximity, by time and location, to the patient may be more beneficial because of SARS-CoV-2 variants. Additional randomized trial data are still accruing and should be incorporated with other trial data to optimize CCP indications.
【초록키워드】 COVID-19, Treatment, coronavirus disease, convalescent plasma, SARS-CoV-2, Efficacy, coronavirus, pandemic, Hospitalized, Trial, antibody, randomized trial, complement, severe acute respiratory syndrome Coronavirus, Health crisis, Complement activation, Health, Viral, SARS-CoV-2 variants, plasma, location, phagocytosis, viral neutralization, United States, respiratory, disease, moderate, safety profile, function, Therapies, antibody-dependent cellular cytotoxicity, immunosuppressed patients, Outpatient, severe disease, Immunosuppressed, CCP, early disease, moderate to severe, symptom onset, acute respiratory syndrome, Activation, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, therapeutic potential, indications, prophylactic therapy, high-titer CCP, The United States, benefit, collected, the patient, provided, provide, immunosuppressed patient, transfused, with COVID-19, 【제목키워드】 COVID-19,