Abstract
Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants.
【초록키워드】 SARS-CoV-2, Vaccine, immune response, vaccination, Immunity, antibody, mRNA vaccine, Antibody Response, variant, Delta, omicron, variants, Spike protein, memory, vaccine dose, BNT162b2, Protein, T cell, understanding, age, Responder, acquired immunity, T cell response, boost, cellular response, Vaccinations, Analysis, dose, Vaccine-induced immunity, Cellular responses, Older, memory immune response, comprehensive analysis, individual, Wuhan strain, vaccinees, responses, vaccinee, identify, develop, less, induce, individuals, sustained, the Spike, 【제목키워드】 vaccination, Immunity, vaccine dose, Lower,