Abstract
Recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may pose a threat to immunity. A systematic landscape of neutralizing antibodies against emerging variants is needed. We systematically searched for studies that evaluated neutralizing antibody titers induced by previous infection or vaccination against SARS-CoV-2 variants and collected individual data. We identified 106 studies meeting the eligibility criteria. Lineage B.1.351 (beta), P.1 (gamma) and B.1.617.2 (delta) significantly escaped natural infection-mediated neutralization, with an average of 4.1-fold (95% confidence interval [CI]: 3.6-4.7-fold), 1.8-fold (1.4-2.4-fold), and 3.2-fold (2.4-4.1-fold) reduction in live virus neutralization assay, while neutralizing titers against B.1.1.7 (alpha) decreased slightly (1.4-fold [95% CI: 1.2-1.6-fold]). Serum from vaccinees also led to significant reductions in neutralization of B.1.351 across different platforms, with an average of 7.1-fold (95% CI: 5.5-9.0-fold) for nonreplicating vector platform, 4.1-fold (3.7-4.4-fold) for messenger RNA platform, and 2.5-fold (1.7-2.9-fold) for protein subunit platform. Neutralizing antibody levels induced by messenger RNA vaccines against SARS-CoV-2 variants were similar to, or higher, than that derived from naturally infected individuals.
Keywords: SARS-CoV-2 variants; natural infection; neutralizing antibodies; vaccination.
【저자키워드】 Neutralizing antibodies, vaccination., SARS-CoV-2 variants, natural infection, 【초록키워드】 neutralizing antibody, SARS-CoV-2, Vaccine, coronavirus, vaccination, Immunity, Neutralizing antibodies, antibody, B.1.351, neutralization, variant, SARS-CoV-2 variant, Infection, B.1.617.2, severe acute respiratory syndrome Coronavirus, variants, serum, SARS-CoV-2 variants, Neutralization assay, B.1.1.7, P.1, Lineage, Alpha, Neutralizing, eligibility criteria, respiratory, natural infection, platform, Antibody titers, Live virus, Neutralizing antibody titer, Neutralizing titer, Protein subunit, titers, (alpha, (Beta), Messenger RNA, acute respiratory syndrome, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, 95% confidence interval, significant reductions, infected individuals, neutralizing antibody titers, average, fold, neutralizing titers, vaccinees, vaccinee, collected, significantly, evaluated, searched, reductions in, reduction in, escaped, 【제목키워드】 SARS-CoV-2, review, coronavirus 2, induced, natural, Against,