Abstract
Polymerase chain reaction (PCR) tests cannot always detect the SARS-CoV-2 virus, possibly due to differences in sensitivity between sample types. Under these circumstances, immunochromatography may serve as an alternative method to detect anti-SARS-CoV-2 IgG antibodies that indicate a history of infection. In our analysis of patients with severe COVID-19 infection, we found that 14 of 19 serum samples were positive for IgG antibodies, whereas 6 of 10 samples from patients with asymptomatic or mild cases were negative. Two patients with immune thrombocytopenia who were treated with prednisolone experienced aggressive COVID-19-related respiratory failure and eventually died. Patients not in remission and those who received steroid-based chemotherapy had a higher risk of death, and patients with lymphoid malignancies including lymphoma and myeloma died in larger numbers than those with myeloid malignancies. A stricter cohorting strategy based on repeat PCR tests or isolation to a private room should be adopted in routine care in hematology departments to prevent viral spread to the environment.
Keywords: Anti-SARS-CoV-2 IgG; COVID-19; Nosocomial infection; Survival.
【저자키워드】 COVID-19, anti-SARS-CoV-2 IgG, Nosocomial infection, Survival., 【초록키워드】 immunochromatography, Respiratory failure, Infection, SARS-CoV-2 virus, viral spread, Chemotherapy, polymerase chain reaction, sensitivity, Myeloma, Viral, PCR, COVID-19 infection, IgG antibodies, anti-SARS-CoV-2 IgG, anti-SARS-CoV-2 IgG antibodies, lymphoma, Patient, Isolation, Nosocomial infection, death, PCR test, Immune thrombocytopenia, Analysis, malignancy, steroid, Prednisolone, can not, Chain Reaction, alternative method, Remission, Severe COVID-19 Infection, higher risk, serum samples, two patients, routine care, positive, lymphoid, serum sample, Prevent, myeloid malignancies, detect, died, treated, Two patient, adopted, anti-SARS-CoV-2 IgG antibody, mild case, patients with asymptomatic, the SARS-CoV-2 virus, 【제목키워드】 COVID-19 pandemic, management, Patient, Japan, disease, hematological,