Abstract
COVID-19 is associated with high mortality in patients with haematological malignancies (HM) and rate of seroconversion is unknown. The ITA-HEMA-COV project ( NCT04352556 ) investigated patterns of seroconversion for SARS-CoV-2 IgG in patients with HMs. A total of 237 patients, SARS-CoV-2 PCR-positive with at least one SARS-CoV-2 IgG test performed during their care, entered the analysis. Among these, 62 (26·2%) had myeloid, 121 (51·1%) lymphoid and 54 (22·8%) plasma cell neoplasms. Overall, 69% of patients (164 of 237) had detectable IgG SARS-CoV-2 serum antibodies. Serologically negative patients (31%, 73 of 237) were evenly distributed across patients with myeloid, lymphoid and plasma cell neoplasms. In the multivariable logistic regression, chemoimmunotherapy [odds ratio (OR), 3·42; 95% confidence interval (CI), 1·04-11·21; P = 0·04] was associated with a lower rate of seroconversion. This effect did not decline after 180 days from treatment withdrawal (OR, 0·35; 95% CI: 0·11-1·13; P = 0·08). This study demonstrates a low rate of seroconversion in HM patients and indicates that treatment-mediated immune dysfunction is the main driver. As a consequence, we expect a low rate of seroconversion after vaccination and thus we suggest testing the efficacy of seroconversion in HM patients.
Keywords: Covid-19; SARS-CoV-2; leukemia; lymphoma; myeloma.
【저자키워드】 COVID-19, SARS-CoV-2, lymphoma, leukemia, myeloma., 【초록키워드】 Treatment, IgG, Efficacy, vaccination, haematological malignancies, Withdrawal, Myeloma, Seroconversion, lymphoma, Patient, plasma, Care, patients, leukemia, myeloid, SARS-CoV-2 IgG, Plasma cell, Analysis, immune dysfunction, Neoplasms, SARS-CoV-2 PCR, malignancy, Chemoimmunotherapy, negative patients, IgG test, plasma cell neoplasms, 95% confidence interval, multivariable logistic regression, PCR-positive, high mortality, HM patients, serum antibodies, lymphoid, Cell, Serologically, performed, investigated, detectable, indicate, HM patient, patients with haematological, rate of seroconversion, 【제목키워드】 malignancy, elicit, antibody response against, patients with haematological,