Abstract
The effects of inactivated SARS-CoV-2 vaccine (CoronaVac) on previously naturally infected individuals are unknown. This study compared immunogenicity and reactogenicity of CoronaVac in once naturally infected health-care workers (HCWs) and uninfected HCWs. All HCWs were immunized with two doses of CoronaVac (600 U/0.5 ml) intramuscularly at a 28-day interval. Adverse reactions were obtained by web-based questionnaires or telephone calls seven days after each vaccine dose. Detection of antibody levels against the receptor-binding domain (RBD) of SARS-CoV-2 spike protein was done four weeks after the second dose of the vaccine. We enrolled 103 previously naturally infected and 627 uninfected HCWs. The mean time for vaccination after the first nasopharyngeal SARS-CoV-2 positivity was 64 days (range: 15-136 days) in previously naturally infected HCWs. Among the previously naturally infected HCWs, 41 (40%) were asymptomatic, 52 (50%) had mild upper respiratory tract infections, 10 (105) had pneumonia, and only 6 (5%) were hospitalized. Any reported adverse reactions, either from the first dose or the second dose of vaccine administration, did not differ between previously infected and uninfected HCWs. Anti-RBD antibody titers were obtained in 50 (51%) of 103 previously infected HCWs and 142 (23%) of 627 uninfected HCWs. Anti-RBD antibody titers were significantly higher in HCWs with a previous natural infection (median 1220 AU/ml, range: 202-10328 AU/mL) than in uninfected HCWs (median: 913 AU/ml, range: 2.8-15547 AU/mL, p = .032). CoronaVac administration was safe and may elicit higher antibody responses in previously naturally infected individuals.
Keywords: CoronaVac; SARS-coV-2 inactivated virus vaccine; Turkey; health care workers; vaccine adverse effects; vaccine antibody response.
【저자키워드】 health care workers, CoronaVac, Turkey, vaccine adverse effects, SARS-coV-2 inactivated virus vaccine, vaccine antibody response., 【초록키워드】 Vaccine, vaccination, immunogenicity, reactogenicity, Health care, Hospitalized, Pneumonia, antibody, health care workers, Antibody Response, CoronaVac, detection, virus, SARS-CoV-2 vaccine, Spike protein, vaccine dose, Respiratory tract infections, Adverse reactions, Health, infections, Receptor-binding domain, Asymptomatic, HCWs, RBD, nasopharyngeal, SARS-CoV-2 spike protein, Antibody titer, Mild, antibody levels, respiratory, natural infection, Care, upper respiratory tract, questionnaire, Antibody titers, inactivated, administration, dose, Adverse reaction, Safe, HCW, second dose, infected individual, infected individuals, first dose, upper respiratory tract infections, SARS-CoV-2 positivity, vaccine administration, uninfected, Effect, immunized, Seven, health-care, enrolled, not differ, reported, median, elicit, the receptor-binding domain, significantly higher, the vaccine, was done, intramuscularly, 【제목키워드】 SARS-CoV-2, SARS-CoV-2 vaccine, Health care worker, inactivated, uninfected,