Abstract
Aims: To assess severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during labor and delivery with polymerase chain reaction (PCR) and using immunoglobulin G and M testing to correlate with maternal and perinatal outcomes.
Main methods: Pregnant women admitted for labor and delivery at two Spanish hospitals were screened for SARS-CoV-2 infection by PCR test and by detection of serum immunoglobulins G and M. Maternal and perinatal outcomes were compared in women with laboratory evidence of SARS-CoV-2 infection with those with negative tests.
Key findings: Between March 31st and September 30th, 2020, 1211 pregnant women were screened for SARS-CoV-2 infection. The prevalence of laboratory evidence of SARS-CoV-2 infections was 5.4% (n = 65), corresponding to (i) 22 ongoing infections at admission, including two with mild clinical symptoms and 20 asymptomatic women; (ii) 43 cases of previous SARS-CoV-2 exposure; (iii) and 1146 women who were negative for both SARS-CoV-2 PCR and serological test. None of the screened mothers required hospital admission for coronavirus disease before or after delivery, nor were any of the newborns admitted to the intensive care unit. All newborns from mothers with positive PCR on admission were PCR negative. There were no significant differences in maternal or perinatal outcomes among the three studied groups.
Significance: Ongoing or previous SARS-CoV-2 infection with asymptomatic or mild clinical symptoms detected during screening in pregnant women at labor and delivery do not have a higher rate of adverse maternal or perinatal outcomes.
Keywords: COVID-19; Coronavirus 2019; Labor and delivery; Polymerase chain reaction; SARS-CoV-2; Serum immunoglobulins.
【저자키워드】 COVID-19, SARS-CoV-2, polymerase chain reaction, Coronavirus 2019, Labor and delivery, serum immunoglobulins, 【초록키워드】 coronavirus disease, serological test, coronavirus, intensive care, SARS-COV-2 infection, immunoglobulins, hospital, Infection, intensive care unit, severe acute respiratory syndrome coronavirus-2, outcome, severe acute respiratory syndrome Coronavirus, Laboratory, pregnant women, Prevalence, outcomes, Severe acute respiratory syndrome, polymerase chain reaction, Immunoglobulin G, Newborn, Maternal, PCR, Asymptomatic, Immunoglobulin, Hospital admission, women, respiratory, PCR test, Admission, SARS-CoV-2 infections, mother, Coronavirus-2, Evidence, SARS-CoV-2 PCR, evidence of, on admission, Chain Reaction, acute respiratory syndrome, no significant differences, acute respiratory syndrome coronavirus, no significant difference, acute respiratory syndrome coronavirus-2, labor, mild clinical symptoms, serum immunoglobulins, positive PCR, Spanish, polymerase chain, required, screened, groups, mild clinical symptom, serum immunoglobulin, 【제목키워드】 Infection, Screening, polymerase chain reaction, respiratory, Coronavirus-2, polymerase chain,