Abstract
Objectives: We aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital.
Methods: Determination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7months.
Results: We included 3062 HCWs; 256 (8.4%) were positive for anti-SARS-CoV-2 nucleocapsid IgG. Among them, early decrease in the anti-nucleocapsid antibody index was observed between the first (S1) and second (S2) serology samplings in 208 HCWs (84.2%). The initial anti-nucleocapsid IgG index seemed to be related to the HCWs’ age. Seventy-four HCWs were included in the 7-month cohort study. Among them, 69 (90.5%) had detectable anti-spike IgG after 7months and 24 (32.4%) reported persistent symptoms consistent with post-acute COVID-19 syndrome diagnosis.
Conclusion: The prevalence of serological positivity among HCWs was 6.7%. Infection should be followed by vaccination because of antibody decrease.
Keywords: Anti-spike IgG; COVID-19; Healthcare workers; SARS-CoV-2; Vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, Healthcare workers, anti-Spike IgG, 【초록키워드】 IgG, immune response, vaccination, pandemic, Healthcare workers, serology, antibody, SARS-COV-2 infection, hospital, Diagnosis, Symptom, anti-SARS-CoV-2, healthcare worker, cohort study, Prevalence, anti-Spike IgG, nucleocapsid, HCWs, age, Follow-up, serological, First wave, Anti-spike, HCW, followed by, syndrome, positive, anti-Nucleocapsid IgG, infection prevalence, decrease, initial, reported, detectable, determine, Determination, offered, 【제목키워드】 anti-SARS-CoV-2, healthcare worker, Cohort, French,