Abstract
Background: Currently, there is no specific drug for the treatment of coronavirus disease 2019 (COVID-19). Therapeutic benefits of intravenous immunoglobulin (IVIG) have been demonstrated in wide range of diseases. The present study is conducted to evaluate the safety and efficacy of IVIG in the treatment of COVID-19 patients with moderate pneumonia.
Methods: An open-label, multicenter, comparative, randomized study was conducted on COVID-19 patients with moderate pneumonia. One hundred eligible patients were randomized in 1:1 ratio either to receive IVIG + standard of care (SOC) or SOC.
Results: Duration of hospital stay was significantly shorter in the IVIG group compared with that of SOC alone (7.7 vs 17.5 days). Duration for normalization of body temperature, oxygen saturation, and mechanical ventilation were significantly shorter in IVIG compared with SOC. Percentages of patients on mechanical ventilation in 2 groups were not significantly different (24% vs 38%). Median time to reverse-transcription polymerase chain reaction negativity was significantly shorter with IVIG than SOC (7 vs 18 days). There were only mild to moderate adverse events in both groups except for 1 patient (2%), who died in SOC.
Conclusions: Intravenous immunoglobulin was safe and efficacious as an adjuvant with other antiviral drugs in the treatment of COVID-19.
Keywords: COVID-19; IVIG; SARS-CoV-2; immunoglobulin; pneumonia.
【저자키워드】 COVID-19, SARS-CoV-2, Pneumonia, IVIG, Immunoglobulin, 【초록키워드】 Treatment, coronavirus disease, Coronavirus disease 2019, Intravenous immunoglobulin, Efficacy, Diseases, Open-label, mechanical ventilation, Pneumonia, antiviral drugs, oxygen, IVIG, antiviral drug, adverse events, Randomized, polymerase chain reaction, oxygen saturation, Duration, Immunoglobulin, adverse event, Patient, Mild, adjuvant, multicenter, group, moderate, body temperature, COVID-19 patients, COVID-19 patient, Safe, Hospital stay, except for, mild to moderate, Chain Reaction, Standard of care, both groups, median time, percentages, randomized study, normalization, therapeutic benefits, negativity, benefit, polymerase chain, evaluate, died, conducted, demonstrated, receive, 1:1, eligible patient, in both group, not significantly different, on mechanical ventilation, percentage, significantly shorter, 【제목키워드】 Coronavirus disease 2019, Safety, Pneumonia, Immunoglobulin, immunoglobulin therapy, phase, Regular,