Abstract
Background: Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be given to unvaccinated patients who experienced COVID-19 early in the pandemic.
Methods: We recruited COVID-19 convalescent individuals who received one or two doses of an mRNA vaccine within 6 or around 18 months after a diagnosis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Their samples were assessed for IgG-binding or neutralizing activity and cell-mediated immune responses against SARS-CoV-2 wild-type and variants of concern.
Results: A total of 43 COVID-19 convalescent individuals were analyzed in the present study. The results showed that humoral and cellular immune responses against SARS-CoV-2 wild-type and variants of concern, including the Omicron variant, were comparable among patients vaccinated within 6 versus around 18 months. A second dose of vaccine did not significantly increase immune responses.
Conclusion: One dose of mRNA vaccine should be considered sufficient to elicit a broad immune response even around 18 months after a COVID-19 diagnosis.
Keywords: COVID-19; Immune response; SARS-CoV-2; Vaccination; mRNA.
【저자키워드】 COVID-19, SARS-CoV-2, immune response, vaccination, mRNA, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Vaccine, immune response, vaccine doses, pandemic, mRNA vaccine, Cellular immune response, variant, Infection, variants of concern, Diagnosis, omicron, variants, vaccine dose, Severe acute respiratory syndrome, Neutralizing activity, mRNA, immune responses, Patient, COVID-19 diagnosis, Omicron variant, respiratory, Guidance, severe acute respiratory syndrome-coronavirus-2, Humoral and cellular immune responses, dose, humoral, second dose, second dose of vaccine, Cell-mediated immune responses, wild-type, cell-mediated immune response, convalescent individuals, convalescent individual, analyzed, significantly, include, recruited, elicit, comparable, were assessed, 【제목키워드】 mRNA vaccination, SARS-COV-2 infection, cellular immunity, humoral, elicited,