Abstract
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age 1,2 . Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C) 3-5 . Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.
【초록키워드】 COVID-19, antibodies, IgG, IgM, Respiratory distress syndrome, ARDS, coronavirus, immune response, acute respiratory distress syndrome, S protein, SARS-COV-2 infection, children, Antibody Response, Infection, Respiratory illness, MIS-C, clinical manifestations, Neutralizing activity, IgG antibody, IgG antibodies, clinical, N protein, age, respiratory, Anti-spike, Protective, specific antibodies, breadth, serological response, acute respiratory distress, New coronavirus, Inflammatory, manifestation, respiratory symptoms, independent of, respiratory distress, IgA antibodies, syndrome, life-threatening, cohorts, new coronavirus SARS-CoV-2, Clinical manifestations of COVID-19, COVID-19 cohort, implication, independent, Course, develop, caused, reduced, the S protein, the N protein, 【제목키워드】 COVID-19, SARS-CoV-2, children, Antibody Response,