Abstract
An 11-year-old boy presented with features resembling those described in health alerts on Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS), including persistent fever, haemodynamic instability and abdominal pain. Laboratory tests, including raised inflammatory markers, D-dimer, troponin and a coagulopathy, were consistent with PIMS-TS. Our patient required transfer to the paediatric intensive care unit; an echocardiography revealed left ventricular dysfunction. He was treated with intravenous immunoglobulins (Igs), corticosteroids and aspirin, with full resolution of clinical symptoms. A follow-up echocardiogram 1 month after discharge was unremarkable.Three SARS-CoV-2 PCRs on respiratory samples, taken over the initial 4-day period, were negative, as was a SARS-CoV-2 PCR on faeces 1 month after presentation; titres of IgG were clearly elevated. The negative PCRs in the presence of elevated titres of IgG suggest that the inflammatory syndrome might have developed in a late phase of COVID-19 infection when the virus was no longer detectable in the upper airway.
Keywords: cardiovascular medicine; immunological products and vaccines; infectious diseases; paediatric intensive care; paediatrics.
【저자키워드】 Infectious diseases, paediatrics, cardiovascular medicine, immunological products and vaccines, paediatric intensive care, 【초록키워드】 Corticosteroid, SARS-CoV-2, IgG, Intravenous immunoglobulin, Corticosteroids, Infectious diseases, intensive care, Clinical symptoms, immunoglobulins, inflammatory markers, D-dimer, troponin, Laboratory tests, abdominal pain, virus, discharge, airway, Coagulopathy, echocardiography, Health, COVID-19 infection, paediatrics, paediatric inflammatory multisystem syndrome, Fever, Patient, Aspirin, Follow-up, respiratory, upper airway, Respiratory samples, Intensive, persistent fever, PIMS, Inflammatory, SARS-CoV-2 PCR, Faeces, left ventricular dysfunction, Echocardiogram, titres, syndrome, transfer, Negative PCR, titre, late phase, ventricular dysfunction, immunological, feature, initial, described, detectable, raised, required, elevated, faece, treated, 【제목키워드】 Inflammatory, syndrome, new virus,