Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China at the end of 2019 has spread throughout the world and caused many thousands of deaths. The previous study reported a higher severe status rate and mortality rate in male patients in China. However, the reason underlying this difference has not been reported. The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. In this study, to compare the differences of the SARS-CoV-2 IgG antibody between male and female patients, a total number of 331 patients confirmed SARS-CoV-2 infection were enrolled. The serum of these patients was collected during hospitalization and detected for the SARS-CoV-2 IgG antibody. Our data showed that the concentration of IgG antibody in mild, general, and recovering patients showed no difference between male and female patients. In severe status, compared with male patients, there were more female patients having a relatively high concentration of serum SARS-CoV-2 IgG antibody. In addition, the generation of IgG antibody in female patients was stronger than male patients in disease early phase. Our study identified a discrepancy in the SARS-CoV-2 IgG antibody level in male and female patients, which may be a potential cause leading to a different outcome of Coronavirus Disease 2019 between sex.
Keywords: COVID-19 patients; SARS-CoV-2 IgG antibody; sexual discrepancy.
【저자키워드】 SARS-CoV-2 IgG antibody, COVID-19 patients, sexual discrepancy., 【초록키워드】 COVID-19, coronavirus disease, convalescent plasma, SARS-CoV-2, IgG, Coronavirus disease 2019, coronavirus, Hospitalization, antibody, SARS-COV-2 infection, Sex, outcome, severe acute respiratory syndrome Coronavirus, Spread, China, serum, Immunoglobulin G, IgG antibody, Immunoglobulin, SARS-CoV-2 IgG antibody, male, Patient, Mild, mortality rate, respiratory, disease, clinical therapy, patients, SARS-CoV-2 IgG, Concentration, deaths, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, no difference, early phase, Female patients, reason, previous study, discrepancy, recovering patients, Effect, enrolled, caused, reported, addition, was collected, recovering patient, female patient, the SARS-CoV-2, 【제목키워드】 COVID-19, Sex, outcome, male, female,