Abstract
Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and possibly exclude the sexual transmission of COVID-19.
Keywords: COVID-19; Expressed prostatic secretion; Prostate; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Expressed prostatic secretion, Prostate, 【초록키워드】 coronavirus disease, SARS-CoV-2, IgM, ACE2, coronavirus, angiotensin converting enzyme 2, interleukin-6, angiotensin converting enzyme, Novel coronavirus, Protein, interleukin, male, Patient, SARS-CoV-2 RNA, cellular entry, patients, COVID-19 patients, Prostate, angiotensin, Inflammatory, COVID-19 patient, erythrocyte sedimentation, prostatic secretion, erythrocyte sedimentation rate, sedimentation rate, two groups, enzyme, serum IgG, pathogenic, negativity, positive, organ, sexual transmission, nasopharyngeal swabbing, susceptible, recruited, elevated, expressed, stratified, modulated, 【제목키워드】 coronavirus, Wuhan, COVID-19 patient, absence, expressed,