Abstract
The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein 1 . Cellular immune responses, particularly CD8 + T cell responses, probably contribute to protection against severe SARS-CoV-2 infection 2-6 . Here we show that cellular immunity induced by current vaccines against SARS-CoV-2 is highly conserved to the SARS-CoV-2 Omicron spike protein. Individuals who received the Ad26.COV2.S or BNT162b2 vaccines demonstrated durable spike-specific CD8 + and CD4 + T cell responses, which showed extensive cross-reactivity against both the Delta and the Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron spike-specific CD8 + T cell responses were 82-84% of the WA1/2020 spike-specific CD8 + T cell responses. These data provide immunological context for the observation that current vaccines still show robust protection against severe disease with the SARS-CoV-2 Omicron variant despite the substantially reduced neutralizing antibody responses 7,8 .
【초록키워드】 SARS-CoV-2, Vaccine, BNT162b2 vaccine, SARS-COV-2 infection, variant, Infection, Delta, omicron, CD4, CD8, Omicron variants, variants, Spike protein, cross-reactivity, BNT162b2, T cell, Ad26.COV2.S, cellular immunity, immune responses, T cell responses, B.1.1.529, T cell response, Neutralizing antibody response, cellular, severe disease, observation, These data, individual, severe SARS, neutralizing antibody responses, fraction, Ad26, WA1/2020, cellular immune responses, BNT162b2 vaccines, subpopulations, effector memory, immunological, severe SARS-CoV-2, robust, shown, conserved, reduced, contribute, demonstrated, mutated, evade, elicited, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, conserved, elicit,