Abstract
Objective: To screen pregnant women at risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery using reverse-transcription polymerase chain reaction (RT-PCR) test and serum immunoglobulin (Ig) testing.
Method: Between March 31 st and August 31 st of 2020, consecutive pregnant women admitted for labor and delivery in a single hospital were screened for SARS-CoV-2 with nasopharyngeal RT-PCR swab tests and detection of serum IgG and IgM.
Results: We studied 266 pregnant women admitted for labor and delivery. The prevalence of acute or past SARS-CoV-2 infection was 9.0 %, including (i) two cases with respiratory symptoms of SARS-Co-V-2 infection and positive RT-PCR; (ii) four asymptomatic women with positive RT-PCR without clinical symptoms and negative serological tests between two and 15 weeks later; and (iii) two women with false positive RT-PCR due to technical problems. All newborns of the 6 pregnant women with RT-PCR positive had negative RT-PCR and did not require Neonatal Intensive Care Unit admission. There were eighteen asymptomatic women with positive serological IgG tests and negative RT-PCR.
Conclusion: In our cohort of gravids, we found 2.2 % of women with positive RT-PRC tests and 6.7 % with positive serological tests during the first wave of the SARS-CoV-2 pandemic.
Keywords: COVID-19; Delivery; Reverse-transcription polymerase chain reaction (RT-PCR); SARS-CoV-2; Screening; serum immunoglobulins.
【저자키워드】 COVID-19, SARS-CoV-2, Screening, delivery, Reverse-transcription polymerase chain reaction (RT-PCR), serum immunoglobulins, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, serological test, IgM, coronavirus, pandemic, Clinical symptoms, SARS-COV-2 infection, SARS-CoV-2 pandemic, immunoglobulins, Infection, intensive care unit, risk, severe acute respiratory syndrome Coronavirus, RT-PCR, pregnant women, Prevalence, polymerase chain reaction, serum, Cohort, Newborn, Serological tests, Asymptomatic, Immunoglobulin, nasopharyngeal, women, Swab test, respiratory, serological, First wave, False positive, Admission, positive RT-PCR, respiratory symptoms, Chain Reaction, IgG test, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, problems, clinical symptom, respiratory symptom, serum IgG, labor, serum immunoglobulins, positive, negative RT-PCR, single hospital, polymerase chain, screened, the SARS-CoV-2, 【제목키워드】 coronavirus, respiratory, acute respiratory syndrome, gravid,