Abstract
Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.
Keywords: COVID-19; D614G; SARS-CoV-2; coronavirus; pandemic; spike protein.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, pandemic, Spike protein, D614G, 【초록키워드】 coronavirus, antibody, Therapeutics, variant, severe acute respiratory syndrome Coronavirus, virus, variants, Spike protein, memory, Humoral immunity, emergence, Patient, D614G, respiratory, Donor, cross-reactive, SARS-CoV-2 disease, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, These data, individual, analyzed, reactivity, 【제목키워드】 spike, Immunoglobulin G, performance, Effect,