Abstract
The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4 + T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.
Keywords: Humoral immunity; Neutralizing antibodies; SARS-CoV-2; Virus-specific T cells.
【저자키워드】 SARS-CoV-2, Neutralizing antibodies, Humoral immunity, Virus-specific T cells., 【초록키워드】 COVID-19, Pathogenesis, Lymphocytes, Neutralizing antibodies, T cells, SARS-COV-2 infection, severity, Infection, CD4, memory, Humoral immunity, Neutralization assay, cellular immunity, information, convalescent patient, humoral and cellular immunity, IFN-γ, convalescent COVID-19 patients, Immune status, cellular, COVID-19 patient, humoral, acute phase, help, T lymphocyte, non-severe patients, vaccine immunity, IFN-γ ELISPOT, Cell, ELISpot testing, involved, detectable, the disease, significantly higher, convalescent COVID-19 patient, 【제목키워드】 clinical, immunological characteristics, COVID-19 convalescent patient,