Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has spread worldwide since it was first identified in Wuhan, China, at the end of 2019. With the global transmission of the virus, a large number of SARS-CoV-2 variants have also appeared, especially, emerging strains that have recently been discovered in the United Kingdom (variant 20I/501Y.V1, lineage B.1.1.7), South Africa (variant 20H/501Y.V2, lineage B.1.351), and Brazil (variant 20 J/501Y.V3, and lineage P.1). The common feature of these variants is that they share the N501Y mutation involving the SARS-CoV-2 spike (S) protein, which is precisely the target of most COVID-19 vaccines. Furthermore, mutations such as N501Y, E484K, and K417N in the S protein may affect viral fitness and transmissibility. However, current research on the impact of these variants on COVID-19 vaccines is still lacking. Herein, we briefly explain why most COVID-19 vaccines target the S protein, update the progress of research regarding S protein-related COVID-19 vaccines, review the latest studies concerning the effects of S protein variants on COVID-19 vaccines, and finally, propose certain strategies to deal with SARS-CoV-2 variants.
Keywords: COVID-19; Mutation; SARS-CoV-2; Spike Protein; Vaccine; Variant.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Mutation, variant, Spike protein, 【초록키워드】 coronavirus disease, Brazil, Coronavirus disease 2019, COVID-19 vaccine, Mutation, S protein, spike, B.1.351, variant, SARS-CoV-2 variant, Transmission, severe acute respiratory syndrome coronavirus-2, severe acute respiratory syndrome Coronavirus, virus, Spike protein, Spread, Severe acute respiratory syndrome, Protein, COVID-19 vaccines, South Africa, Viral, Transmissibility, SARS-CoV-2 variants, B.1.1.7, N501Y, K417N, P.1, Wuhan, Research, Lineage, E484K, target, N501Y mutation, Lineage B.1.1.7, respiratory, United Kingdom, SARS-CoV-2 spike, Coronavirus-2, strain, causative agent, acute respiratory syndrome, acute respiratory syndrome coronavirus, lineage B.1, viral fitness, Effect, Affect, Wuhan, China, the S protein, explain, concerning, S protein variant, the SARS-CoV-2, 【제목키워드】 Spike protein, failure, the Spike,