Abstract
Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related viruses. Here, we structurally identified a YYDRxG motif encoded by IGHD3-22 in CDR H3 that facilitates antibody targeting to a functionally conserved epitope on the SARS-CoV-2 receptor binding domain. A computational search for a YYDRxG pattern in publicly available sequences uncovered 100 such antibodies, many of which can neutralize SARS-CoV-2 variants and SARS-CoV. Thus, the YYDRxG motif represents a common convergent solution for the human humoral immune system to target sarbecoviruses including the Omicron variant. These findings suggest an epitope-targeting strategy to identify potent and broadly neutralizing antibodies for design of pan-sarbecovirus vaccines and antibody therapeutics.
【초록키워드】 neutralizing antibody, antibodies, SARS-CoV-2, Vaccine, Neutralizing antibodies, antibody, SARS-CoV, Antibody Response, variant, SARS-CoV-2 variant, immune system, omicron, Receptor binding domain, Antibody therapeutics, SARS-CoV-2 variants, Omicron variant, epitope, antigenic variants, Sarbecoviruses, sarbecovirus, Human immune system, humoral, sequence, motif, SARS-related viruses, neutralize, CDR H3, IGHD3-22, identify, conserved, facilitate, respond, the antibody response, antigenic variant, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, neutralization, Human, variants of concern, omicron, binding, motif,