Abstract
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
Keywords: COVID-19; CSF; IgG; SARS-CoV-2; neurological symptoms; serology.
【저자키워드】 COVID-19, SARS-CoV-2, IgG, serology, Neurological symptoms, CSF, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, serology, antibody, disease severity, Antibody Response, severe acute respiratory syndrome Coronavirus, Spike protein, Predictive value, serum, Antibody responses, Immunoglobulin G, Immunoglobulin, Patient, Central nervous system, Neurological symptoms, cerebrospinal fluid, respiratory, serological, SARS-CoV-2 IgG, marker, neurological, Predictive, acute respiratory syndrome, clinical variables, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, virus spike protein, independent, Neurological symptom, highest, tested, elevated, Level, neuronal, were assessed, 【제목키워드】 coronavirus 2, response,