Abstract
Background: Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required.
Methods/results: By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson’s syndrome (catastrophic antiphospholipid syndrome).
Conclusion: A parallelism between this severe form of COVID-19 and Asherson’s syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.
Keywords: Abnormal immunothrombosis; Antiphospholipid syndrome (Hughes syndrome); Asherson’s syndrome; Coronavirus disease 2019 (COVID-19); Lupus anticoagulant (LAC); Megakaryocytes.
【저자키워드】 Coronavirus disease 2019 (COVID-19), Abnormal immunothrombosis, Antiphospholipid syndrome (Hughes syndrome), Asherson’s syndrome, Lupus anticoagulant (LAC), Megakaryocytes., 【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, Hospitalization, hypercytokinemia, viral infections, immunothrombosis, Coagulation, Viral, male, Patient, death, Lupus, multiple organ failure, disease, Care, mechanism, lupus anticoagulant, Disseminated intravascular coagulation, thrombotic microangiopathy, Anticoagulant, Genetic predisposition, multidisciplinary approach, overlapping, complex, syndrome, thrombotic, high mortality rate, intravascular coagulation, approach, catastrophic, develop, occurred, the disease, required, condition, 【제목키워드】 COVID-19, immunothrombosis, Anticoagulant, syndrome, catastrophic,