Abstract
Population-based immunoglobulin G (IgG) seroprevalence studies in asymptomatic individuals in Latin America are scarce. The objective of the study was to estimate the prevalence and geographic distribution of IgG antibodies induced by natural SARS-CoV-2 infection in asymptomatic adults, 5-8 months after the first case was reported in a northeastern state of Mexico. This was a population-based cross-sectional study carried out in Nuevo Leon during August-November 2020. Individuals ≥18 years with no previous diagnosis or symptoms suggestive of COVID-19 were consecutively screened in one of the busiest subway stations. Also, a search for eligible individuals was done from house-to-house, after selecting densely populated geographic sectors of each of the municipalities of the metropolitan area (n = 4495). The IgG antibodies to SARS-CoV-2 nucleocapsid protein were analyzed. The IgG antibody positivity rate was 27.1% (95% confidence interval [CI]: 25.8, 28.4); there were no differences by sex or age (p > 0.05). Analysis by month showed a gradual increase from 11.9% (August) to 31.9% (November); Week 39 had the highest positivity rate (42.2%, 95% CI: 34.2, 50.7). Most people did not have evidence of previous SARS-CoV-2 infection. Preventive measures and promotion of the COVID-19 vaccine should be strengthened.
Keywords: COVID-19; IgG; SARS-CoV2; coronavirus; seroprevalence.
【저자키워드】 COVID-19, IgG, coronavirus, SARS-CoV2, Seroprevalence, 【초록키워드】 COVID-19 vaccine, cross-sectional, SARS-COV-2 infection, Diagnosis, Sex, Symptom, nucleocapsid protein, Prevalence, Protein, Adults, Immunoglobulin G, cross-sectional study, IgG antibody, Asymptomatic individuals, Asymptomatic, Immunoglobulin, IgG antibodies, Latin America, age, preventive measures, distribution, Evidence, Geographic distribution, evidence of, preventive measure, previous diagnosis, 95% CI, 95% confidence interval, house, individual, no difference, no differences, promotion, SARS-CoV-2 nucleocapsid, MOST, asymptomatic individual, highest, analyzed, carried, reported, screened, was done, eligible, Week, 【제목키워드】 virus, Asymptomatic,