Abstract
Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.
Keywords: Antibody; COVID-19; ECLIA; ELISA; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, ELISA, ECLIA, 【초록키워드】 coronavirus disease, SARS-CoV-2, IgG, Coronavirus disease 2019, antibody, Antibody Response, Infection, ELISA, Severe acute respiratory syndrome, Neutralizing activity, SARS-CoV-2 antibodies, SARS-CoV-2 antibody, Serosurvey, Immunoglobulin, virus neutralization test, neutralization test, understanding, respiratory, severe acute respiratory syndrome-coronavirus-2, surrogate virus neutralization test, anti-S IgG, waning immunity, sVNT, mild COVID-19 patients, positive, mildly symptomatic patients, commercial immunoassay, investigated, the antibody response, kinetics of antibody, mildly symptomatic patient, 【제목키워드】 SARS-CoV-2, response, Year,