Abstract
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.
Keywords: COVID-19; Complement-mediated coagulopathy; Thrombosis.
【저자키워드】 COVID-19, thrombosis, Complement-mediated coagulopathy, 【초록키워드】 SARS-CoV-2, thrombosis, severe COVID-19, antibody, Diabetes Mellitus, Type 2 diabetes mellitus, complement, diabetes, Coagulopathy, Nasopharyngeal swab, Patient, SARS-CoV-2 RNA, antiphospholipid antibodies, anticardiolipin antibodies, Nasopharyngeal swab specimens, Vascular injury, specimen, positive, nasopharyngeal swab specimen, tested, performed, demonstrated, suggested, contributed, viral-induced, declined, type 2 diabete, 【제목키워드】 thrombosis,