Abstract
Kawasaki disease (KD) and multisystem inflammatory syndrome (MIS) are rare conditions that occur predominately in children. Recent reports document KD and MIS in adult patients following infection with SARS-CoV-2. Rarely, MIS is observed following vaccination against SARS-CoV-2, mostly in patients with prior SARS-CoV-2 infection. We report a case of KD in a man after a second SARS-CoV-2 vaccine dose, in absence of concurrent or prior SARS-CoV-2 infection. This patient also met criteria for probable MIS associated with vaccination. He tested negative for SARS-CoV-2 RNA via reverse transcriptase PCR, negative for SARS-CoV-2 nucleocapsid antibodies and demonstrated high levels SARS-CoV-2 spike protein antibodies, commonly used to assess vaccine response. Symptom improvement followed treatment with intravenous immunoglobulin, including desquamation of the hands and feet. As widespread vaccination against SARS-CoV-2 continues, increased vigilance and prompt intervention is necessary to limit the effects of postvaccination inflammatory syndromes.
Keywords: COVID-19; Immunological products and vaccines; Rheumatology; Unwanted effects / adverse reactions; Vaccination/immunisation.
【저자키워드】 COVID-19, rheumatology, immunological products and vaccines, Unwanted effects / adverse reactions, Vaccination/immunisation., 【초록키워드】 Treatment, antibodies, SARS-CoV-2, Intravenous immunoglobulin, vaccination, antibody, SARS-COV-2 infection, children, Intervention, SARS-CoV-2 vaccine, Spike protein, Adverse reactions, Immunoglobulin, vaccine response, SARS-CoV-2 spike protein, Kawasaki disease, rheumatology, Patient, SARS-CoV-2 RNA, reverse transcriptase PCR, dose, Inflammatory, criteria, reverse transcriptase, hands, Adult patients, syndrome, SARS-CoV-2 nucleocapsid, postvaccination, Effect, widespread, MIS, recent, limit, desquamation, tested, condition, absence, occur, demonstrated, infection with SARS-CoV-2, 【제목키워드】 SARS-CoV-2 vaccination, Inflammatory, syndrome,