Abstract
The antibody titer of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed in 289 healthy healthcare workers who had completed the second dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Antibody tests were performed using both the automated electrochemiluminescence immunoassay (ECLIA) and the chromatographic lateral flow immunoassay (LFIA). All subjects had antibodies against the receptor binding domain of the spike protein of SARS-CoV-2 only one week after completing the vaccination, and the antibody titer became significantly higher after another week ( P < 0.001). Since there was a large amount of antibody formation within two weeks after completion of vaccination, the less sensitive method, LFIA, also showed high sensitivity. There was no significant difference between whole blood and serum in detecting SARS-CoV-2 antibodies after vaccination. This is an early study of vaccinations among Koreans and is expected to contribute to the establishment of national guidelines on COVID-19 vaccination.
Keywords: Antibody Formation; COVID-19; Immunoassay; Korean; SARS-CoV-2; mRNA Vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, mRNA vaccine., immunoassay, antibody formation, Korean, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Vaccine, coronavirus, vaccination, antibody, mRNA vaccine, severe acute respiratory syndrome Coronavirus, healthcare worker, Spike protein, Receptor binding domain, immunoassay, serum, sensitivity, SARS-CoV-2 antibodies, SARS-CoV-2 antibody, COVID-19 vaccination, Whole blood, antibody tests, mRNA, Antibody titer, LFIA, respiratory, Pfizer-BioNTech, antibody formation, Korean, Vaccinations, acute respiratory syndrome, significant difference, acute respiratory syndrome coronavirus, no significant difference, acute respiratory syndrome coronavirus 2, subject, second dose, all subjects, completion, automated electrochemiluminescence, national guidelines, Koreans, performed, healthy, less, contribute, the spike protein, significantly higher, expected, chromatographic lateral flow, national guideline, 【제목키워드】 Pfizer-BioNTech, worker, second, Week,