Abstract
The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.
Keywords: COVID-19; SARS-CoV-2; antibodies; dynamics; humoral immunity.
【저자키워드】 COVID-19, antibodies, SARS-CoV-2, Dynamics, Humoral immunity, 【초록키워드】 IgG, antibody, ELISA, Spike protein, Receptor binding domain, Antigen, Protein, Humoral immunity, IgG antibody, COVID-19 infection, IgG antibodies, IgM antibodies, RBD, recombinant antigens, Patient, characteristic, Blood, Recombinant spike protein, Spike proteins, IgG and IgM, determined by, venous blood, IgM antibody, observation period, Confirmed COVID-19 infection, recombinant spike proteins, virion, N-protein, venous, remained, the disease, was determined, reflect, the Spike, 【제목키워드】 Confirmed, the SARS-CoV-2,