Abstract
Objectives: To evaluate whether a third vaccination shows an added effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell responses in patients with multiple sclerosis treated with ocrelizumab or fingolimod.
Methods: This is a substudy of a prospective multicenter study on SARS-CoV-2 vaccination in patients with immune-mediated diseases. Patients with MS treated with ocrelizumab, fingolimod, and no disease-modifying therapies and healthy controls were included. The number of interferon (IFN)-γ secreting SARS-CoV-2-specific T cells at multiple time points before and after 3 SARS-CoV-2 vaccinations were evaluated.
Results: In ocrelizumab-treated patients (N = 24), IFN-γ-producing SARS-CoV-2-specific T-cell responses were induced after 2 vaccinations with median levels comparable to healthy controls (N = 12) and patients with MS without disease-modifying therapies (N = 10). A third vaccination in ocrelizumab-treated patients (N = 8) boosted T-cell responses that had declined after the second vaccination, but did not lead to higher overall T-cell responses as compared to immediately after a second vaccination. In fingolimod-treated patients, no SARS-CoV-2-specific T cells were detected after second (N = 12) and third (N = 9) vaccinations.
Discussion: In ocrelizumab-treated patients with MS, a third SARS-CoV-2 vaccination had no additive effect on the maximal T-cell response but did induce a boost response. In fingolimod-treated patients, no T-cell responses could be detected following both a second and third SARS-CoV-2 vaccination.
【초록키워드】 SARS-CoV-2, coronavirus, vaccination, therapy, multiple sclerosis, T cells, T-cell Response, interferon, severe acute respiratory syndrome Coronavirus, Patient, multicenter, respiratory, fingolimod, patients, T-cell responses, SARS-CoV-2 vaccination, boost, SARS-CoV-2-specific T cells, Ocrelizumab, Vaccinations, lead, additive effect, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, second vaccination, healthy control, healthy controls, immune-mediated diseases, evaluate, evaluated, median, treated, added, induce, comparable, had no, secreting, declined, SARS-CoV-2-specific T cell, SARS-CoV-2-specific T-cell response, 【제목키워드】 SARS-CoV-2, response, longitudinal, Multiple, sclerosis,