Abstract
The clinical course of COVID-19 is very heterogeneous: most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We performed a biomarker study to assess the impact of prior infections with seasonal coronaviruses on COVID-19 severity. Sixty patients with confirmed COVID-19 infections were included (age 30-82; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease, and 25 outpatients. Patients with critical disease had significantly lower levels of anti-HCoV OC43-NP (P = 0.016) and HCoV HKU1-NP (P = 0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that prior infections with seasonal coronaviruses might protect against a severe course of disease.
Keywords: COVID-19; HKU1; OC43; Seasonal coronaviruses.
【저자키워드】 COVID-19, seasonal coronaviruses, OC43, HKU1, 【초록키워드】 Coronaviruses, Biomarker, intensive care, antibody, Infection, COVID-19 severity, Clinical course, HCoV, Patient, age, outpatients, seasonal coronaviruses, seasonal coronavirus, disease, OC43, HKU1, COVID-19 patients, Critical disease, Inpatient, moderate disease, infected individual, COVID-19 infections, Confirmed COVID-19 infection, significantly lower, seasonal, males, PROTECT, Course, resulting, performed, proportion, 【제목키워드】 Course, human coronavirus, elevated, levels of antibody,