Abstract
Background: Which are the consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant (LT) recipients?
Methods: We attempted to address this question by reviewing our single-center experience during the first 2 months of the pandemics at a high incidence area.
Results: Nineteen adult patients (5 females) were diagnosed by May 5, 2020. Median age was 58 (range 55-72), and median follow-up since transplantation was 83 (range 20-183) months. Cough (84.2%), fever (57.9%), and dyspnea (47.4%) were the most common symptoms. Thirteen patients (68.4%) had pneumonia in x-ray/CT scan. Hydroxychloroquine was administered in 11 patients, associated with lopinavir/ritonavir and interferon β in 2 cases each. Immunomodulatory therapy with tocilizumab was used in 2 patients. Immunosuppression (IS) was halted in one patient and modified in only other two due to potential drug interactions. Five (26.3%) patients were managed as outpatient. Two patients (10.5%) died, 10 (52.6%) were discharged home, and 2 (10.5%) were still hospitalized after a median follow-up of 41 days from the onset of symptoms. Baseline IS regimen remained unchanged in all surviving recipients, with good liver function.
Conclusions: Our preliminary experience shows a broad spectrum of disease severity in LT patients with COVID-19, with a favorable outcome in most of them without needing to modify baseline IS.
Keywords: COVID-19; SARS-CoV2; immunosuppression; liver transplant; prognosis.
【저자키워드】 COVID-19, SARS-CoV2, Prognosis, Immunosuppression, liver transplant, 【초록키워드】 SARS-CoV-2, coronavirus, therapy, Lopinavir/ritonavir, Hydroxychloroquine, Prognosis, Tocilizumab, Pneumonia, disease severity, Lopinavir, Ritonavir, Infection, interferon, Immunosuppression, outcome, severe acute respiratory syndrome Coronavirus, Symptoms, X-ray, CT scan, Fever, Dyspnea, Patient, Pandemics, Liver function, age, Follow-up, incidence, respiratory, liver, patients, liver transplant, immunomodulatory therapy, Outpatient, broad spectrum, Drug interactions, transplantation, regimen, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, recipients, median age, one patient, two patients, single-center, Administered, females, consequence, discharged home, was used, died, remained, diagnosed, median, Two patient, question, onset of symptoms, modify, baseline, patients with COVID-19, still hospitalized, 【제목키워드】 SARS-COV-2 infection, outcome, Spain, liver, liver transplant, single center,