Abstract
Treatment options for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) are limited with no clarity on efficacy and safety profiles. We performed a systematic review and meta-analysis of studies on patients ≥18 years reporting data on therapeutic interventions in SARS-CoV-2. Primary outcome was all-cause mortality and secondary outcomes were rates of mechanical ventilation, viral clearance, adverse events, discharge, and progression to severe disease. Pooled rates and odds ratios (OR) were calculated. Twenty-nine studies with 5207 patients were included. Pooled all-cause mortality in intervention arm was 12.8% (95% confidence interval [CI]: 8.1%-17.4%). Mortality was significantly higher for studies using hydroxychloroquine (HCQ) for intervention (OR: 1.36; 95% CI: 0.97-1.89). Adverse events were also higher in HCQ subgroup (OR: 3.88; 95% CI: 1.60-9.45). There was no difference in other secondary outcomes. There is a need for well-designed randomized clinical trials for further investigation of every therapeutic intervention for further insight into different therapeutic options.
Keywords: COVID-19; HCQ; SARS-CoV-2; hydroxychloroquine; meta-analysis.
【저자키워드】 COVID-19, Meta-analysis, SARS-CoV-2, Hydroxychloroquine, HCQ, 【초록키워드】 Meta-analysis, randomized clinical trial, Hydroxychloroquine, mechanical ventilation, clinical trials, systematic review, Intervention, progression, outcome, discharge, viral clearance, adverse events, Severe acute respiratory syndrome, Viral, Patient, Efficacy and safety, Severe acute respiratory syndrome-related coronavirus, respiratory, therapeutic options, Coronavirus-2, Odds ratio, severe disease, Severe acute respiratory syndrome-related coronavirus-2, acute respiratory syndrome, Adverse, Primary outcome, 95% confidence interval, Secondary outcomes, no difference, Odds ratios, all-cause mortality, profiles, secondary outcome, therapeutic interventions, therapeutic intervention, intervention arm, event, Pooled rates, performed, calculated, significantly higher, 【제목키워드】 Treatment, SARS-COV-2 infection, Effectiveness,