Abstract
Background: We previously reported elsewhere of a follicular lymphoma patient suffering from persistent COVID-19 pneumonia that was still ongoing at 2 months after onset.
Materials and methods: We provide a follow-up report of the case along with a literature review of immunocompromised lymphoma patients experiencing prolonged COVID-19 infections.
Results: Although requiring a full 1 year, the presented case eventually achieved spontaneous resolution of COVID-19 pneumonia. Anti-SARS-CoV-2 antibodies could not be detected throughout the disease course, but COVID-19-directed T-cell response was found to be intact. The patient also developed secondary immune thrombocytopenia subsequent to COVID-19 pneumonia. We found 19 case reports of immunocompromised lymphoma patients with prolonged COVID-19 infections in the literature. All 5 patients who died did not receive convalescent plasma therapy, whereas resolution of COVID-19 infection was achieved in 8 out of 9 patients who received convalescent plasma therapy.
Conclusions: We demonstrate through the presented case that while time-consuming, resolution of COVID-19 infections may be achieved without aid from humoral immunity if cellular immunity is intact. Immunocompromised lymphoma patients are at risk of a prolonged disease course of COVID-19, and convalescent plasma therapy may be a promising approach in such patients.
Keywords: Anti-sars-cov-2 antibodies; Chemotherapy; Convalescent plasma; Coronavirus; Itp.
【저자키워드】 convalescent plasma, coronavirus, Chemotherapy, anti-SARS-CoV-2 antibodies, Itp., 【초록키워드】 COVID-19, convalescent plasma, COVID-19 pneumonia, Pneumonia, antibody, T-cell Response, risk, Case report, Chemotherapy, anti-SARS-CoV-2 antibodies, Humoral immunity, Convalescent plasma therapy, COVID-19 infection, cellular immunity, lymphoma, Patient, Immunocompromised, Follow-up, thrombocytopenia, patients, Immune thrombocytopenia, Follicular lymphoma, literature review, COVID-19 infections, disease course, material, prolonged disease, approach, Course, died, reported, subsequent, the disease, time-consuming, receive, follicular, 【제목키워드】 COVID-19, review, rituximab, Follow-up, literature, development, Prolonged, Resolution, maintenance, report,