Abstract
This case series describes three patients affected by severe acute respiratory syndrome coronavirus 2, who developed polyradiculoneuritis as a probable neurological complication of coronavirus disease 2019 (COVID-19). A diagnosis of Guillain Barré syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis, and electroneurography. In all of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 gr/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases, a significant decrease in amplitude of compound motor action potential cMAP. Due to the potential role of inflammation on symptoms development and prognosis, interleukin-6 (IL-6) and IL-8 levels were measured in serum and cerebrospinal fluid during the acute phase, while only serum was tested after recovery. Both IL-6 and IL-8 were found increased during the acute phase, both in the serum and cerebrospinal fluid, whereas 4 months after admission (at complete recovery), only IL-8 remained elevated in the serum. These results confirm the inflammatory response that might be linked to peripheral nervous system complications and encourage the use of IL-6 and IL-8 as prognostic biomarkers in COVID-19.
Keywords: COVID-19; IL-6; IL-8; interleukins; polyradiculonevritis.
【저자키워드】 COVID-19, Interleukins, IL-6, IL-8, polyradiculonevritis, 【초록키워드】 coronavirus disease, severe acute respiratory syndrome coronavirus 2, Prognostic biomarkers, Inflammation, Coronavirus disease 2019, Intravenous immunoglobulin, coronavirus, Interleukins, Clinical symptoms, Prognosis, IL-6, interleukin-6, Diagnosis, Symptom, severe acute respiratory syndrome Coronavirus, serum, interleukin, Immunoglobulin, clinical, Patient, nervous system, IL-8, Complication, Neurological symptoms, cerebrospinal fluid, respiratory, Admission, prognostic biomarker, Inflammatory response, administration, Therapeutic approach, Analysis, Peripheral nervous system, neurological, complete recovery, acute respiratory syndrome, action potential, conduction block, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, acute phase, syndrome, significant decrease, amplitude, electroneurography, F waves, polyradiculoneuritis, affected, remained, elevated, case sery, absence, were measured, was tested, 【제목키워드】 Interleukins, Patient,