Abstract
Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 µg/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations.
【초록키워드】 viruses, SARS-CoV-2, Saliva, SARS-COV-2 infection, Infection, virus, anti-SARS-CoV-2, Antiviral effect, Wuhan, Gamma, Alpha, Beta, Bacteria, Mouthwash, fungi, Concentration, Analysis, Ammonium, chloride, sucrose, cetylpyridinium chloride, microscopic examination, wild-type SARS-CoV-2, SARS-CoV-2 strain, experimental evidence, Cetylpyridinium, Effect, effective, concentrations, conducted, provided, demonstrated, suppressed, disrupting, inhibit SARS-CoV-2, 【제목키워드】 SARS-CoV-2,